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FLASH GENE
Symbol RILPL1 contributors: mct - updated : 23-03-2022
HGNC name Rab interacting lysosomal protein-like 1
HGNC id 26814
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY regulatory
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,cytosolic
intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
intracellular,nucleus,nucleoplasm
text
  • RILPL1 and RILPL2 both localize to the primary cilium and centrosome, RILPL1 specifically to the distal end of the mother centriole (pMID: 23264467)
  • is predominantly localized in the cytoplasm
  • RILPL1 localizes to a pericentriolar compartment adjacent to the mother centriole
    • basic FUNCTION
  • may physiologically regulate the viability of neurons and other cells
  • participate in the regulation of ciliary membrane content by promoting protein removal from the primary cilium
  • RILPL1 and RILPL2 regulate protein localization in the primary cilium
  • RILPL1 and RILPL2 function in regulation of ciliary membrane protein concentration by promoting protein removal from the primary cilium
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds GAPDH, in competition with SIAH1, retaining GAPDH in the cytosol and preventing its nuclear translocation (
  • NPM1 did not compete with RILPL1 for GAPDH binding in the cytoplasm, although a small amount of NPM1 protein was able to reside in the cytoplasm
  • loss of RILPL1 abolishes the LRRK2-mediated deficits in centrosome cohesion
  • RAB12 interacts with RILP, RILPL1 and RILPL2 independently of each other
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) OPDM4
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS