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FLASH GENE
Symbol TMEM71 contributors: mct - updated : 18-05-2011
HGNC name transmembrane protein 71
HGNC id 26572
DNA
TYPE functioning gene
STRUCTURE 50.72 kb     10 Exon(s)
regulatory sequence Promoter
Binding site
text structure
  • both ING2 and SiIN3A are present on TMEM71 promoter in an ING2 sumoylation-dependent manner to mediate the expression of this gene
    • MAPPING cloned   linked   status
    RNA
    TRANSCRIPTS type
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 2105 - 276 - 2010 20676127
    9 - 1973 - 232 - 2010 20676127
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • its expression is dependent on SIN3A and ING2
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein interacting with ING2 (ING2 must be sumoylated to bind to the promoter of TMEM71 and to recruit the SIN3A chromatin-modifying complex to this promoter, in order to regulate TMEM71 transcription
    cell & other
    REGULATION
    Other its regulation may be directly mediated by ING2
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS