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FLASH GENE

Symbol

LRRC3B

contributors: mct - updated : 28-03-2011

HGNC name	leucine rich repeat containing 3B
HGNC id	28105

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

Homologene

FAMILY

CATEGORY

DNA associated , tumor suppressor

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION	might be regulated by DNA methylation and had an important role in DNA repair
	confers resistance to UV damage and accelerates the DNA repair rate
	putative tumor suppressor silenced in gastric cancers by epigenetic mechanisms and its silencing in cancer may play an important role in tumor escape from immune surveillance
	may be a novel methylation-sensitive tumor suppressor gene in CRC (colorectal cancer)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   methylation intensity was significantly higher in colorectal cancer tissues than in the corresponding non-cancerous tissues tumoral     --low   by hypermethylation (promoter region of LRRC3B was aberrantly methylated) in gastric cancer

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS