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FLASH GENE
Symbol LRRC3B contributors: mct - updated : 28-03-2011
HGNC name leucine rich repeat containing 3B
HGNC id 28105
DNA
TYPE functioning gene
STRUCTURE 87.97 kb     2 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
2 - 1718 - 259 - 2008 18377727
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY DNA associated , tumor suppressor
SUBCELLULAR LOCALIZATION     plasma membrane
basic FUNCTION
  • might be regulated by DNA methylation and had an important role in DNA repair
  • confers resistance to UV damage and accelerates the DNA repair rate
  • putative tumor suppressor silenced in gastric cancers by epigenetic mechanisms and its silencing in cancer may play an important role in tumor escape from immune surveillance
  • may be a novel methylation-sensitive tumor suppressor gene in CRC (colorectal cancer)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    methylation intensity was significantly higher in colorectal cancer tissues than in the corresponding non-cancerous tissues
    tumoral     --low  
    by hypermethylation (promoter region of LRRC3B was aberrantly methylated) in gastric cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS