Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol LBH contributors: mct - updated : 23-11-2010
HGNC name limb bud and heart development homolog (mouse)
HGNC id 29532
PROTEIN
PHYSICAL PROPERTIES acid
STRUCTURE
motifs/domains
  • a conserved putative nuclear localization signal
  • a glutamate-rich putative transcriptional activation domain but lacks a DNA binding domain (DBD)
    • HOMOLOGY
    Homologene
    FAMILY
  • LBH family
    • CATEGORY regulatory , transcription factor , tumor suppressor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text localized to both the nucleus and the cytoplasm
    basic FUNCTION
  • may have an important role of Lbh in transcriptional control during normal cardiogenesis
  • may act as a transcriptional activator in mitogen-activated protein kinase signaling pathway to mediate cellular functions
  • during endochondral bone formation, may negatively regulate vascular invasion and formation of the early ossification center at least in part by interfering with RUNX2 and/or VEGFA expression
  • key transcriptional regulator of vertebrate development
  • linked to the Wnt signaling pathway in both development and cancer
  • may act as a downstream effector of canonical Wnt/CTNNB signaling in both normal and neoplastic epithelial development, which is under the tight control of antagonistic noncanonical WNT7A signaling
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with alphaB-crystallin, CRYAB (interaction that may inhibit synergistically the transcriptional regulation of TP53 and CDKN1A)
  • canonical Wnt target gene
    • cell & other
    REGULATION
    Other its expression is tightly controlled by Wnt signaling
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in aggressive basal subtype breast cancers that display Wnt/beta-catenin hyperactivation
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker potential new marker for therapeutically challenging basal-like breast cancers
    Therapy target
    ANIMAL & CELL MODELS