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FLASH GENE
Symbol MURC contributors: mct - updated : 03-11-2010
HGNC name muscle-related coiled-coil protein
HGNC id 33742
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
  • PTRF/SDPR family
    • CATEGORY motor/contractile
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text
  • localized to the cytoplasm with accumulation in the Z-line of the sarcomere
    • basic FUNCTION
  • modulates RHOA signaling and plays an important role in the development of cardiac dysfunction and conduction disturbance with increased vulnerability to atrial arrhythmias
  • involved in the skeletal myogenesis that results from modulation of myogenin expression and ERK activation
  • may play pivotal roles in the molecular mechanisms of skeletal myogenic differentiation
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • MURC is a target of SDPR, a phosphatidylserine-binding protein
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    during injury-induced muscle regeneration, MURC expression increased, and a higher abundance of MURC was observed in immature myofibers compared with mature myofibers
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Transgenic mice expressing cardiac-specific MURC (Tg-MURC) exhibited cardiac contractile dysfunction and atrioventricular (AV) conduction disturbances with atrial chamber enlargement, reduced thickness of the ventricular wall, and interstitial fibrosis