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FLASH GENE
Symbol MURC contributors: mct - updated : 03-11-2010
HGNC name muscle-related coiled-coil protein
HGNC id 33742
Location 9q31.1      Physical location : 103.340.335 - 103.350.171
DNA
TYPE functioning gene
STRUCTURE 9.84 kb     2 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
2 - 2640 - 364 - -
EXPRESSION
Rna function mRNA expression in the heart increased during the developmental process from the embryonic stage to adulthood
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
 vesselaorta   
Respiratorylung    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumcardiac  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
  • PTRF/SDPR family
  • CATEGORY motor/contractile
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text
  • localized to the cytoplasm with accumulation in the Z-line of the sarcomere
  • basic FUNCTION
  • modulates RHOA signaling and plays an important role in the development of cardiac dysfunction and conduction disturbance with increased vulnerability to atrial arrhythmias
  • involved in the skeletal myogenesis that results from modulation of myogenin expression and ERK activation
  • may play pivotal roles in the molecular mechanisms of skeletal myogenic differentiation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • MURC is a target of SDPR, a phosphatidylserine-binding protein
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    during injury-induced muscle regeneration, MURC expression increased, and a higher abundance of MURC was observed in immature myofibers compared with mature myofibers
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Transgenic mice expressing cardiac-specific MURC (Tg-MURC) exhibited cardiac contractile dysfunction and atrioventricular (AV) conduction disturbances with atrial chamber enlargement, reduced thickness of the ventricular wall, and interstitial fibrosis