Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

TMEM38A

contributors: mct - updated : 16-12-2015

HGNC name	transmembrane protein 38A
HGNC id	28462

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       moderately Nervous brain       moderately

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal   highly Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	four transmembrane-spanning alpha helices
	C-terminal domain faces the cytoplasmic side of the endo(sarco)plasmic reticulum

HOMOLOGY

Homologene

FAMILY

CATEGORY

transport channel

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,organelle,endoplasmic reticulum
	intracellular,nucleus
	intracellular,nuclear envelope
text	distributed in both longitudinal tubules and terminal cisternae of the sarcoplasmic reticulum, as well as in the perinuclear membrane systems and the nuclear envelope of myotubes and adult fibres
	predominantly expressed in the sarcoplasmic reticulum (SR) of muscle cells

basic FUNCTION	TMEM38A, TMEM38B channels are likely to act as counter-ion channels that function in synchronization with Ca2+ release from intracellular stores
	may be involved in the structural organization or function of the molecular machinery underlying excitation-contraction coupling
	act as novel monovalent cation-specific channels on intracellular membrane systems
	TMEM38A, TMEM38B, seem to have differential functions in Ca(2+) signaling in excitable and nonexcitable cells
	directly modulates the function of the cardiac ryanodine receptor 2 Ca(2+) release channel, which in turn controls store-overload-induced Ca(2+) release from the SR

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component	part of TRIC channels that are likely to act as counter-ion channels that function in synchronization with Ca2+ release from intracellular stores
	constituent of the skeletal muscle SR (sarcoplasmic reticulum)

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

Tric-a(-/-) mice display defective Ca(2+) sparks and spontaneous transient outward currents in arterial smooth muscle and develop hypertension, in addition to skeletal muscle dysfunction