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FLASH GENE
Symbol XPNPEP3 contributors: mct - updated : 06-06-2019
HGNC name X-prolyl aminopeptidase (aminopeptidase P) 3, putative
HGNC id 28052
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Endocrinepancreas   highly
Nervousbrain   highly
Reproductivemale systemtestis  highly
Urinarykidney   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
  • peptidase M24B family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • aminopeptidase activity
  • having a likely cilia-related function
  • transcriptional target of Wnt/CTNNB1 pathway with particular significance for colorectal cancer (CRC)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • XPNPEP3-mediated TNFR2 signal transduction mechanism that induces activation of JNK1 and JNK2
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) NPHPL1
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in tumors exhibiting activated Wnt/CTNNB1 signaling
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS