| Other morbid association(s)
|
| Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
|---|
| tumoral
|
|
| --over
|
|
to melanoma formation by preventing stress-induced apoptotic death mediated by the MEK/ERK signaling pathway, especially in acral lentiginous melanoma  | | constitutional
|
|
| --low
|
| |
by excitotoxicity and cerebral ischaemia contributed to neuronal death | | constitutional
|
|
| --over
|
| |
in necropsies from AD patients where it accumulates with hyperphosphorylated MAPT, and is phosphorylated by GSK3B in AD brain, wich could be protecting KIDINS220 from calpain cleavage, contributing to accumulation of this protein in AD samples | |
