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FLASH GENE

Symbol

TMX3

contributors: mct/npt - updated : 24-06-2010

HGNC name	thioredoxin-related transmembrane protein 3
HGNC id	24718

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	41.43 kb     16 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_019022 16 - 4767 NP_061895 - 454 - Haugstetter (2007)

EXPRESSION

Type

expressed in	(based on citations)
organ(s)

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	N-terminal redox-active domain (named a) followed by two enzymatically inactive domains (b and b')(Haugstetter 2007)
	ER-targeting signal sequence
	one Trx-like domain with a catalytic CXXC motif
	one transmembrane domain (Sugiura 2010)
	a C-terminal KKKD tetrapeptide sequence that matches the classical KKXX-type consensus sequence for ER retrieval of type I transmembrane proteins (Haugstetter 2005)

HOMOLOGY

Homologene

FAMILY	TMX family proteins
	protein disulfide isomerase family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,organelle,endoplasmic reticulum

basic FUNCTION	having an oxidase activity, and in tissue-culture cells the protein was found partially in the oxidized form, potentially suggesting a function of the protein as a dithiol oxidase (Haugstetter 2005)
	have isomerase activity in the ER (Sugiura 2010)
	thiol-disulfide oxidoreductase of the protein disulfide-isomerase family (Haugstetter 2007)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS