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FLASH GENE
Symbol TMX3 contributors: mct/npt - updated : 24-06-2010
HGNC name thioredoxin-related transmembrane protein 3
HGNC id 24718
Location 18q22.1      Physical location : 66.340.926 - 66.382.353
Synonym name
  • protein disulfide isomerase family A, member 13
  • protein disulfide-isomerase TMX3
  • thioredoxin domain containing 10
    • Synonym symbol(s) FLJ20793, KIAA1830, PDIA13, TXNDC10
    EC.number 5.3.4.1
    DNA
    TYPE functioning gene
    STRUCTURE 41.43 kb     16 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    16 - 4767 - 454 - Haugstetter (2007)
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal redox-active domain (named a) followed by two enzymatically inactive domains (b and b')(Haugstetter 2007)
  • ER-targeting signal sequence
  • one Trx-like domain with a catalytic CXXC motif
  • one transmembrane domain (Sugiura 2010)
  • a C-terminal KKKD tetrapeptide sequence that matches the classical KKXX-type consensus sequence for ER retrieval of type I transmembrane proteins (Haugstetter 2005)
    • HOMOLOGY
    Homologene
    FAMILY
  • TMX family proteins
  • protein disulfide isomerase family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • having an oxidase activity, and in tissue-culture cells the protein was found partially in the oxidized form, potentially suggesting a function of the protein as a dithiol oxidase (Haugstetter 2005)
  • have isomerase activity in the ER (Sugiura 2010)
  • thiol-disulfide oxidoreductase of the protein disulfide-isomerase family (Haugstetter 2007)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS