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FLASH GENE
Symbol RADIL contributors: mct - updated : 17-09-2018
HGNC name Ras association and DIL domains
HGNC id 22226
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   moderately
Digestiveliver   lowly
Endocrinepancreas   highly
Lymphoid/Immunespleen   lowly
Nervousbrainhindbraincerebellum highly
Reproductivefemale systemovary  moderately
 male systemtestis  highly
Respiratorylung   moderately
Urinarykidney   lowly
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text brain (moderately), liver (lowly)
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a RAS association domain
  • a PDZ domain
  • a DIL domain
  • one FHA domain
    • conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to murine Radil (81.8pc)
    homolog to rattus Radil (81.8pc)
    Homologene
    FAMILY
  • RADIL family
    • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule
    text G-betaGamma and activated RAP1A promote the translocation of RADIL to the plasma membrane at sites of cell-matrix contacts
    basic FUNCTION
  • downstream effector of RAP1A required for cell adhesion and migration of neural crest precursors during development
  • RADIL, a novel RAP1A effector, regulates ITGB1, ITGB2 activation and controls neutrophil chemotaxis
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • component of a complex (RAP1A-RADIL) required downstream of receptor stimulation for the activation of integrins and the positive modulation of cell-matrix adhesiveness
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding RAP1A in a GTP-dependent manner
  • KIF14 associates with the PDZ domain of RADIL and negatively regulates RAP1A-mediated inside-out integrin activation by tethering RADIL on microtubules
  • RASIP1 cooperates with its close relative RAS-association and dilute domain-containing protein (RADIL) to inhibit RHO-mediated stress fiber formation and induces junctional tightening
  • RAP1A effectors RADIL and RASIP1, together with the RHO GTPase activating protein ARHGAP29, mediate RAP1A-induced inhibition of RHO signaling in the processes of epithelial cell spreading and endothelial barrier function
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS