Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

RADIL

contributors: mct - updated : 17-09-2018

HGNC name	Ras association and DIL domains
HGNC id	22226

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_018059 15 - 3682 NP_060529 - 1075 - 2007 PMID: 177043

EXPRESSION

Type

expressed in

(based on citations)

organ(s)

System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       moderately Digestive liver       lowly Endocrine pancreas       highly Lymphoid/Immune spleen       lowly Nervous brain hindbrain cerebellum   highly Reproductive female system ovary     moderately   male system testis     highly Respiratory lung       moderately Urinary kidney       lowly

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal

Text	brain (moderately), liver (lowly)

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a RAS association domain
	a PDZ domain
	a DIL domain
	one FHA domain

conjugated

PhosphoP

HOMOLOGY

interspecies	homolog to murine Radil (81.8pc)
	homolog to rattus Radil (81.8pc)

Homologene

FAMILY

RADIL family

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,cytoskeleton,microtubule
text	G-betaGamma and activated RAP1A promote the translocation of RADIL to the plasma membrane at sites of cell-matrix contacts

basic FUNCTION	downstream effector of RAP1A required for cell adhesion and migration of neural crest precursors during development
	RADIL, a novel RAP1A effector, regulates ITGB1, ITGB2 activation and controls neutrophil chemotaxis

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

signal transduction

a component

component of a complex (RAP1A-RADIL) required downstream of receptor stimulation for the activation of integrins and the positive modulation of cell-matrix adhesiveness

INTERACTION

DNA

RNA

small molecule

protein	binding RAP1A in a GTP-dependent manner
	KIF14 associates with the PDZ domain of RADIL and negatively regulates RAP1A-mediated inside-out integrin activation by tethering RADIL on microtubules
	RASIP1 cooperates with its close relative RAS-association and dilute domain-containing protein (RADIL) to inhibit RHO-mediated stress fiber formation and induces junctional tightening
	RAP1A effectors RADIL and RASIP1, together with the RHO GTPase activating protein ARHGAP29, mediate RAP1A-induced inhibition of RHO signaling in the processes of epithelial cell spreading and endothelial barrier function

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS