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FLASH GENE

Symbol

HOTAIR

contributors: mct - updated : 09-07-2018

HGNC name	hox transcript antisense RNA (non-protein coding)
HGNC id	33510

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional       gain of function in senescent cells, causing rapid decay of targets ATXN1 and SNUPN, and preventing premature senescence tumoral     --over   in breast cancer, both JMJD6 and HOTAIR RNAs increase tumor growth and associate with poor prognosis constitutional     --over   promoted the onset of ischemic infarct induced by hypoxia constitutional     --low   in the spermatozoa of patients with asthenozoospermia and oligoasthenozoospermia, which resulted in down-regulation of NFE2L2 expression

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	serum HOTAIR might serve as a potential biomarker for the diagnosis of esophageal squamous cell carcinoma (ESCC)
	HOTAIR may be regarded as a novel indicator of poor prognosis in diffuse large B cell lymphoma (DLBCL)
	HOTAIR can serve as a common molecular marker for lymph node metastasis
Therapy target
	System Type Disorder Pubmed cancer digestive liver may be a therapeutic target for diagnosing and treating hepatocellular carcinoma (HCC) neurology neurodegenerative Parkinson/dementia Parkinsonism inhibition of HOTAIR levels is an effective disease-modifying strategy in PD cancer eye   has the potential to enhance the development of novel targeted diagnostic and therapeutic approaches for retinoblastoma cancer hemopathy   potential target for gene therapy in the treatment of DLBCL cancer digestive   HOTAIR/WIF1 axis represented a novel therapeutic target in patients with esophageal squamous cell carcinoma (ESCC)

ANIMAL & CELL MODELS