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FLASH GENE
Symbol HOTAIR contributors: mct - updated : 09-07-2018
HGNC name hox transcript antisense RNA (non-protein coding)
HGNC id 33510
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
HOMOLOGY
Homologene
FAMILY
CATEGORY
SUBCELLULAR LOCALIZATION
CELLULAR PROCESS
PHYSIOLOGICAL PROCESS
PATHWAY
metabolism
signaling
a component
INTERACTION
DNA
RNA
small molecule
protein
cell & other
REGULATION
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional       gain of function
in senescent cells, causing rapid decay of targets ATXN1 and SNUPN, and preventing premature senescence
tumoral     --over  
in breast cancer, both JMJD6 and HOTAIR RNAs increase tumor growth and associate with poor prognosis
constitutional     --over  
promoted the onset of ischemic infarct induced by hypoxia
constitutional     --low  
in the spermatozoa of patients with asthenozoospermia and oligoasthenozoospermia, which resulted in down-regulation of NFE2L2 expression
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
  • serum HOTAIR might serve as a potential biomarker for the diagnosis of esophageal squamous cell carcinoma (ESCC)
  • HOTAIR may be regarded as a novel indicator of poor prognosis in diffuse large B cell lymphoma (DLBCL)
  • HOTAIR can serve as a common molecular marker for lymph node metastasis
    • Therapy target
    SystemTypeDisorderPubmed
    cancerdigestiveliver
    may be a therapeutic target for diagnosing and treating hepatocellular carcinoma (HCC)
    neurologyneurodegenerativeParkinson/dementia Parkinsonism
    inhibition of HOTAIR levels is an effective disease-modifying strategy in PD
    cancereye 
    has the potential to enhance the development of novel targeted diagnostic and therapeutic approaches for retinoblastoma
    cancerhemopathy 
    potential target for gene therapy in the treatment of DLBCL
    cancerdigestive 
    HOTAIR/WIF1 axis represented a novel therapeutic target in patients with esophageal squamous cell carcinoma (ESCC)
    ANIMAL & CELL MODELS