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FLASH GENE
Symbol HOTAIR contributors: mct - updated : 09-07-2018
HGNC name hox transcript antisense RNA (non-protein coding)
HGNC id 33510
EXPRESSION
Rna function
  • HOTAIR directly decreased WIF1 expression by promoting its histone H3K27 methylation in the promoter region and then activated the WNT/CTNNB1 signaling pathway
  • is an inducer of ubiquitin-mediated proteolysis
  • associates with E3 ubiquitin ligases bearing RNA-binding domains, DZIP3 and MEX3B, as well as with their respective ubiquitination substrates, ATXN1 and SNUPN
  • ERBB2, MYC, WIF1, RBM38, PTEN, are involved in the HOTAIR regulation network
  • critical role of HOTAIR in serous ovarian cancer (SOC)cell proliferation
  • HOTAIR may play important roles in retinoblastoma progression via Notch pathway
  • promotes Parkinson disease by upregulating LRRK2 expression
  • plays a key role in the progression of various carcinomas
  • HOTAIR promoted glycolysis by upregulating SLC2A1 and activating mammalian target of rapamycin (MTOR) signaling
  • JMJD6 regulates HOTAIR independent of ER status
  • PUM1 regulates HOTAIR expression via a posttranscriptional mechanism
    • Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY
    SUBCELLULAR LOCALIZATION
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional       gain of function
    in senescent cells, causing rapid decay of targets ATXN1 and SNUPN, and preventing premature senescence
    tumoral     --over  
    in breast cancer, both JMJD6 and HOTAIR RNAs increase tumor growth and associate with poor prognosis
    constitutional     --over  
    promoted the onset of ischemic infarct induced by hypoxia
    constitutional     --low  
    in the spermatozoa of patients with asthenozoospermia and oligoasthenozoospermia, which resulted in down-regulation of NFE2L2 expression
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • serum HOTAIR might serve as a potential biomarker for the diagnosis of esophageal squamous cell carcinoma (ESCC)
  • HOTAIR may be regarded as a novel indicator of poor prognosis in diffuse large B cell lymphoma (DLBCL)
  • HOTAIR can serve as a common molecular marker for lymph node metastasis
    • Therapy target
    SystemTypeDisorderPubmed
    cancerdigestiveliver
    may be a therapeutic target for diagnosing and treating hepatocellular carcinoma (HCC)
    neurologyneurodegenerativeParkinson/dementia Parkinsonism
    inhibition of HOTAIR levels is an effective disease-modifying strategy in PD
    cancereye 
    has the potential to enhance the development of novel targeted diagnostic and therapeutic approaches for retinoblastoma
    cancerhemopathy 
    potential target for gene therapy in the treatment of DLBCL
    cancerdigestive 
    HOTAIR/WIF1 axis represented a novel therapeutic target in patients with esophageal squamous cell carcinoma (ESCC)
    ANIMAL & CELL MODELS