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FLASH GENE
Symbol PTPRR contributors: mct - updated : 12-05-2010
HGNC name protein tyrosine phosphatase, receptor type, R
HGNC id 9680
EXPRESSION
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal proteolytic processing, in between amino acid position 136 and 137
  • a tyrosine-protein phosphatase domain
    • HOMOLOGY
    Homologene
    FAMILY
  • protein-tyrosine phosphatase family
  • receptor class 7 subfamily
    • CATEGORY enzyme , receptor
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • sequesters mitogen-activated protein kinases (MAPKs) such as MAPK1, MAPK3 and MAPK14 in the cytoplasm in an inactive form
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral fusion      
    ETV6/PTPRR in acute myelogenous leukemia with inv(12)(p13q13)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS