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FLASH GENE

Symbol

PTPRR

contributors: mct - updated : 12-05-2010

HGNC name	protein tyrosine phosphatase, receptor type, R
HGNC id	9680

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_002849 14 - 3492 NP_002840 - - - - NM_130846 10 - 2733 NP_570897 - 412 - -

EXPRESSION

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	N-terminal proteolytic processing, in between amino acid position 136 and 137
	a tyrosine-protein phosphatase domain

HOMOLOGY

Homologene

FAMILY	protein-tyrosine phosphatase family
	receptor class 7 subfamily

CATEGORY

enzyme , receptor

SUBCELLULAR LOCALIZATION

basic FUNCTION

sequesters mitogen-activated protein kinases (MAPKs) such as MAPK1, MAPK3 and MAPK14 in the cytoplasm in an inactive form

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral fusion       ETV6/PTPRR in acute myelogenous leukemia with inv(12)(p13q13)

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS