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FLASH GENE
Symbol ZG16B contributors: mct/npt - updated : 24-10-2017
HGNC name zymogen granule protein 16 homolog B (rat)
HGNC id 30456
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies ortholog to murine Dcpp1
Homologene
FAMILY
  • jacalin lectin family
    • CATEGORY protooncogene
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • important role in the metastasis and progression of pancreatic carcinoma (Lee 2010)
  • enhances the metastatic potential of pancreatic cancer cells, at least in part, by upregulating CXCR4 expression (Lee 2010)
  • secretory protein involved in pancreatic cancer progression and might be a potential target for the treatment of pancreatic cancer (Kim 2009)
  • promotes metastasis by regulating TLR/CXCR4 activation
  • novel role for ZG16B as a potent endothelial activator, promoting both angiogenesis and vascular permeability
  • can induce activation and maturation of DCs and activate NFKB1 by stimulating the Toll-like receptor signaling pathway
  • soluble protein involved in pancreatic tumorigenesis and metastasis, plays a role as an enhancer of tumor-infiltrating myeloid-derived suppressor cells (MDSCs) and its functional activity
  • plays a major role in Pancreatic tumor progression and metastasis by autocrine and paracrine manners
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • activates the ERK, JNK and AKT signaling pathways and each pathway contributes to the motility of pancreatic cancer cells (Lee 2010)
  • induces CXCR4 expression, which contributes to ZG16B-mediated stimulation of motility of pancreatic cancer cells (Lee 2010)
  • induces extracellular signal-regulated kinase (ERK) phosphorylation and activates the IKBKB-mediated TPL2/MEK/ERK signaling pathway through TLR2
  • ZG16B-mediated PTK2 activation plays an important role in pancreatic cancer progression
  • SIRT1 inhibits proliferation of ZG16B, a novel oncogene, by suppression of CTNNB1
  • conferred resistance to pancreatic cancer cells against oncolytic parvovirus H-1 infection through IFNAR1-mediated signaling
  • ZG16B mediated DC activation and immune stimulation are dependent on TLR4
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in pancreatic ductal adenocarcinoma (Lee 2010)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target novel target for therapeutic intervention to treat human pancreatic cancer ( Lee 2010)
    SystemTypeDisorderPubmed
    cancerendocrinepancreas
    therapeutic potential for targeting ZG16B in pancreatic cancers
    ANIMAL & CELL MODELS