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FLASH GENE
Symbol SHISA9 contributors: mct - updated : 13-04-2010
HGNC name shisa homolog 9 (Xenopus laevis)
HGNC id 37231
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an N-terminal signal sequence
  • a cysteine-rich extracellular domain
  • a transmembrane domain
  • a cytoplasmic segment that terminates in a PDZ type II ligand motif
  • extracellular Cys-knot that might well interact with the extracellular domain of the AMPARs
  • C-terminal PDZ-like ligand motif (PDZ-like interaction site could be necessary for the postsynaptic localization of the membrane-bound Shisa9)
    • HOMOLOGY
    Homologene
    FAMILY
  • shisha protein family
    • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
    text
  • type I transmembrane protein, that is localized in spine heads
  • synaptically localized
    • basic FUNCTION
  • modulates short-term plasticity at specific excitatory synapses
  • operate as an endogenous modulator of the AMPARs
  • differentially modulates short-term plasticity in dentate gyrus synapses (von Engelhardt 2010)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • constituent of AMPAR complexes
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • associates with AMPA receptors in synaptic spines
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS