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FLASH GENE
Symbol SHISA9 contributors: mct - updated : 13-04-2010
HGNC name shisa homolog 9 (Xenopus laevis)
HGNC id 37231
EXPRESSION
Rna function higher in the granule cell layer of dentate gyrus
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain   specific
 brainlimbic systemhippocampusdentate gyrushighly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an N-terminal signal sequence
  • a cysteine-rich extracellular domain
  • a transmembrane domain
  • a cytoplasmic segment that terminates in a PDZ type II ligand motif
  • extracellular Cys-knot that might well interact with the extracellular domain of the AMPARs
  • C-terminal PDZ-like ligand motif (PDZ-like interaction site could be necessary for the postsynaptic localization of the membrane-bound Shisa9)
    • HOMOLOGY
    Homologene
    FAMILY
  • shisha protein family
    • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
    text
  • type I transmembrane protein, that is localized in spine heads
  • synaptically localized
    • basic FUNCTION
  • modulates short-term plasticity at specific excitatory synapses
  • operate as an endogenous modulator of the AMPARs
  • differentially modulates short-term plasticity in dentate gyrus synapses (von Engelhardt 2010)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • constituent of AMPAR complexes
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • associates with AMPA receptors in synaptic spines
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS