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FLASH GENE
Symbol IFNGR2 contributors: mct - updated : 11-07-2015
HGNC name interferon gamma receptor 2 (interferon gamma transducer 1)
HGNC id 5440
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two fibronectin type 3 domains
  • C-terminal region (AAs 296-337) contains a novel BAX inhibitory domain, and has antiapoptotic activity as a BAX inhibitor
    • HOMOLOGY
    Homologene
    FAMILY
  • type II cytokine receptor family
    • CATEGORY signaling cytokine , receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,cytosolic,vesicle
    text located in large vesicles in the cytoplasm, with perinuclear localization typical of the secretory pathway
    basic FUNCTION
  • accessory factor, required for signal transduction
  • associates with ANXA5 and regulates IFN-gamma signaling
  • influence of a mutation in IFNGR2 in human cells on the generation of Th17 cells in memory T cells
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the IFNgamma receptor complex along with the IFNgammaR alpha chain (IFNgammaR1)
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • BAX suppressor
  • interacting with ANXA5
  • JAK2 is a critical factor that stabilizes IFNGR2 surface expression in Th17 cells from active multiple sclerosis (AMS) patients, making them sensitive to IFNG
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) IFNGR2D
    Susceptibility
  • to liver fibrosis in patients with chronic hepatitis C infection
  • to tuberculosis (TB)
    • Variant & Polymorphism SNP
  • two SNPs in strong linkage disequilibrium (LD) in IFNGR2 were significantly associated with liver fibrosis in patients with chronic hepatitis C infection
  • polymorphisms of IFNGR2 may confer resistance to the TB development of newly infected individuals
    • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS