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FLASH GENE
Symbol IFNGR2 contributors: mct - updated : 11-07-2015
HGNC name interferon gamma receptor 2 (interferon gamma transducer 1)
HGNC id 5440
DNA
TYPE functioning gene
STRUCTURE 34.63 kb     7 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
7 - 2234 - 337 - 1994 8124717
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Endocrinepancreas   highly
Nervousbrain   highly Homo sapiens
Respiratorylung   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousastrocyte Homo sapiens
Nervousglia Homo sapiens
Nervousoligodendrocyte Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two fibronectin type 3 domains
  • C-terminal region (AAs 296-337) contains a novel BAX inhibitory domain, and has antiapoptotic activity as a BAX inhibitor
  • HOMOLOGY
    Homologene
    FAMILY
  • type II cytokine receptor family
  • CATEGORY signaling cytokine , receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,cytosolic,vesicle
    text located in large vesicles in the cytoplasm, with perinuclear localization typical of the secretory pathway
    basic FUNCTION
  • accessory factor, required for signal transduction
  • associates with ANXA5 and regulates IFN-gamma signaling
  • influence of a mutation in IFNGR2 in human cells on the generation of Th17 cells in memory T cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the IFNgamma receptor complex along with the IFNgammaR alpha chain (IFNgammaR1)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • BAX suppressor
  • interacting with ANXA5
  • JAK2 is a critical factor that stabilizes IFNGR2 surface expression in Th17 cells from active multiple sclerosis (AMS) patients, making them sensitive to IFNG
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) IFNGR2D
    Susceptibility
  • to liver fibrosis in patients with chronic hepatitis C infection
  • to tuberculosis (TB)
  • Variant & Polymorphism SNP
  • two SNPs in strong linkage disequilibrium (LD) in IFNGR2 were significantly associated with liver fibrosis in patients with chronic hepatitis C infection
  • polymorphisms of IFNGR2 may confer resistance to the TB development of newly infected individuals
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS