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FLASH GENE
Symbol GRXCR1 contributors: npt/mct - updated : 01-03-2010
HGNC name glutaredoxin, cysteine rich 1
HGNC id 31673
Corresponding disease
DFNB25 neurosensory deafness 25
Location 4p13      Physical location : 42.895.282 - 43.032.673
Synonym name glutaredoxin domain-containing cysteine-rich protein 1
DNA
TYPE functioning gene
STRUCTURE 137.39 kb     4 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 991 - 290 - Schraders (2010)
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestineduodenum  
Hearing/Equilibriumearinnercochlea predominantly
Nervousbrain    
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text preferential expression of the gene in fetal cochlea (Schraders 2010)
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • glutaredoxin catalytic domain
  • a GRX-like domain, involved in reversible S-glutathionylation of proteins and thereby in the modulation of activity and/or localization of these proteins (Schraders 2010)
  • a cysteine-rich C-terminal region
  • HOMOLOGY
    Homologene
    FAMILY
  • GRXCR1 family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microfilament
    text localized along the length of stereocilia, the actin-filament-rich mechanosensory structures at the apical surface of auditory and vestibular hair cells (Odeh 2010)
    basic FUNCTION
  • role in modulating actin cytoskeletal architecture in the developing stereocilia of sensory hair cells (Odeh 2010)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) DFNB25
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    Loss of function of Grxcr1 in homozygous pirouette mice results in abnormally thin and slightly shortened stereocilia (Odeh 2010)