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FLASH GENE

Symbol

NTF3

contributors: mct - updated : 05-02-2018

HGNC name	neurotrophin 3
HGNC id	8023

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   in brain, likely to contribute to autistic pathology not only by affecting brain axonal targeting and synapse formation but also by further exacerbating oxidative stress and possibly contributing to Purkinje cell abnormalities constitutional     --over   elevated serum levels of NGF, NTF3, and NTF4 , in patients with mastocytosis

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed neurosensorial ear   Transplantation of neurotrophin over-expressing Schwann cells into the cochlea may provide an alternative means of delivering neurotrophic factors to the deaf cochlea for therapeutic purposes (PMID: 18304740) neurosensorial visual retina modulation of the neuroprotective action of mature NTF3 and pro-apoptotic pro-NTF3/NGFR signaling may represent a novel pharmacological strategy for photoreceptor protection in retinal disease

ANIMAL & CELL MODELS

	muscles of adult Ntf3-deficient animals were weaker than those of wild-type animals to both nerve and direct muscle stimulation
	excessive astrocyte-derived neurotrophin-3 contributes to the abnormal neuronal dendritic development in a mouse model of fragile X syndrome