motifs/domains
| an N-terminal diaphanous inhibitory domain (DID), and this DID-containing N terminus of INF2 does not directly bind the Rho GTPase CDC42  |
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an FH1 domain and a dimeric formin homology 2 (FH2) domain that binds filament barbed ends and is critical for polymerization and depolymerization activities , and the (FH2) domain accelerates actin filament assembly and remains at the barbed end, modulating elongation |
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a C-terminal diaphanous autoregulatory domain (DAD)/ WASP homology-2 (WH2) domain, actin monomer-binding, required for depolymerization activity, and also serves as a diaphanous autoregulatory domain (DAD), which binds to the N-terminal diaphanous inhibitory domain (DID) , but do not display barbed end binding abilities , and WH2 domain of INF2 might aid in actin nucleation, in a manner perhaps similar to FMNL3 and other formins |
| basic FUNCTION
| formin protein with the unique biochemical ability to accelerate actin filament depolymerization |
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physiologically, INF2 acts in the secretory pathway |
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INF2 and stable, detyrosinated microtubules are central players in centrosome reorientation in T cells |
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upon TCR triggering the INF2 formin, together with the formins DIAPH1 and FMNL1, promotes the formation of a specialized array of stable detyrosinated MT that breaks the symmetrical organization of the T-cell microtubule (MT) cytoskeleton |
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unusual formin protein in that it accelerates both actin polymerization and depolymerization, the latter through an actin filament-severing activity |
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important role for the formin INF2 in specifying the function of fibrillar focal adhesions (FAs) through its ability to generate dorsal stress fibers (SFs) |
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in addition to the common formin ability to accelerate actin nucleation and elongation, INF2 can also sever filaments and accelerate their depolymerization |
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FHOD1 and INF2 are novel components and additional actin-based regulators of podosomes in primary human macrophages |
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FHOD1 and INF2 are novel regulators of inter- and intra-structural contractility of podosomes |
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encoding a diaphanous formin family protein that regulates actin cytoskeleton dynamics, and cause human focal segmental glomerulosclerosis (FSGS) |
