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FLASH GENE

Symbol

SLFN11

contributors: mct/npt - updated : 21-12-2016

HGNC name	schlafen family member 11
HGNC id	26633

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
SPECIAL FEATURE	component of a cluster
STRUCTURE	23.40 kb     7 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_152270 5 - 5015 NP_689483 - 901 - 2009 19592487 variant 5 NM_001104590 7 - 5122 NP_001098060 - 901 - 2009 19592487 variant 4 NM_001104589 6 - 5132 NP_001098059 - 901 - 2009 19592487 variant 3 NM_001104588 7 - 5210 NP_001098058 - 901 - 2009 19592487 variant 2 NM_001104587 7 - 5292 NP_001098057 - 901 - 2009 19592487 variant 1

EXPRESSION

Type

expressed in	(based on citations)
organ(s)

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic monocyte Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

common N-terminal (AAA) domain that is involved in GTP/ATP binding (Katsoulidis 2009)

HOMOLOGY

Homologene

FAMILY

schlafen family

CATEGORY

immunity/defense

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm
	intracellular,nucleus,nucleoplasm

basic FUNCTION	control cell cycle progression and growth arrest (Katsoulidis 2009)
	promote growth inhibitory responses and modulate cell cycle progression by inhibiting cyclin D1 (Katsoulidis 2009)
	SLFN11 expression is causally associated with the activity of DNA-damaging agents (DDAs) in cancer cells
	is likely a component of the DNA damage response, enforcing cell cycle arrest and apoptosis in response to exogenous DNA injuries
	inhibits checkpoint maintenance and homologous recombination repair by promoting the destabilization of the RPA-ssDNA complex, thereby sensitizing cancer cell lines expressing high endogenous levels of SLFN11 to DNA-damaging agents
	RPA1-binding ability of SLFN11 is required for its function in the DNA damage response

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	ETS1 acts as a positive regulator for SLFN11 expression in breast cancer cells
	SLFN11 interacts directly with RPA1 and is recruited to sites of DNA damage in an RPA1-dependent manner

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   correlate with the sensitivity of human cancer cells to DNA-damaging agent

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	SLFN11 expression can serve as a biomarker to predict responses to DNA-damaging therapeutic agents
Therapy target

ANIMAL & CELL MODELS