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FLASH GENE
Symbol NAPRT1 contributors: SGE/npt - updated : 15-01-2010
HGNC name nicotinate phosphoribosyltransferase domain containing 1
HGNC id 30450
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated PhosphoP
mono polymer homomer , dimer
HOMOLOGY
interspecies homolog to murine Naprt1 (84.5pc)
homolog to rattus Naprt1 (81.6pc)
Homologene
FAMILY
  • NAPTRase family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • catalyzes the formation of NaMN in the presence of NA, Mg2+ and PRPP
  • is essential for NA to increase cellular NAD levels and thus to prevent oxidative stress of the cells (Hara 2007)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism cofactor
    signaling
    NAD+ biosynthesis
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Mg2+
    • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS