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FLASH GENE
Symbol NAPRT1 contributors: SGE/npt - updated : 15-01-2010
HGNC name nicotinate phosphoribosyltransferase domain containing 1
HGNC id 30450
Location 8q24.3      Physical location : 144.656.955 - 144.660.513
Synonym name
  • FHA-HIT-interacting protein
  • nicotinic acid phosphoribosyltransferase
  • NAPRTase
    • Synonym symbol(s) PP3856, FHIP
    EC.number 2.4.2.11
    DNA
    TYPE functioning gene
    STRUCTURE 3.56 kb     13 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    13 - 1715 - 538 - -
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    conjugated PhosphoP
    mono polymer homomer , dimer
    HOMOLOGY
    interspecies homolog to murine Naprt1 (84.5pc)
    homolog to rattus Naprt1 (81.6pc)
    Homologene
    FAMILY
  • NAPTRase family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • catalyzes the formation of NaMN in the presence of NA, Mg2+ and PRPP
  • is essential for NA to increase cellular NAD levels and thus to prevent oxidative stress of the cells (Hara 2007)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism cofactor
    signaling
    NAD+ biosynthesis
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Mg2+
    • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS