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Symbol VMA21 contributors: shn/npt - updated : 07/12/2009
HGNC name VMA21 vacuolar H+-ATPase homolog (S. cerevisiae)
HGNC id 22082
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies ortholog to Vma21, Mus musculus
ortholog to VMA21, pan troglodytes
Homologene
FAMILY
  • VMA21 family
    • CATEGORY receptor membrane
    SUBCELLULAR LOCALIZATION intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • required for the assembly of the V0 complex of the vacuolar ATPase (V-ATPase) in the endoplasmic reticulum - an essential assembly chaperone of the V-ATPase,the principal mammalian proton pump complex - has a major role in autophagy, long-live protein degradation and vacuolation (Ramachandran 2009)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism protein
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) MEAX
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS