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FLASH GENE
Symbol LRSAM1 contributors: mct/npt - updated : 24-12-2015
HGNC name leucine rich repeat and sterile alpha motif containing 1
HGNC id 25135
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a RING finger domain necessary for multiple mono-ubiquitylation of TSG101 (Amit 2004)
    • conjugated PhosphoP
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY enzyme , regulatory
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • represents a novel signaling protein that mediates components of the Wnt/wingless signaling pathway and cell adhesion in PC12 cells (Li 2003)
  • regulates a TSG101-associated complex responsible for the sorting of cargo into cytoplasm-containing vesicles that bud at the multivesicular body and at the plasma membrane (Amit 2004)
  • polyubiquitinates lysine residues in the C-terminus of uncomplexed TSG101, resulting in proteasomal degradation (McDonald 2009)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • LRSAM1 is a regulator of TSG101 expression
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CMT2P
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS