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FLASH GENE

Symbol

RASSF10

contributors: mct/npt/pgu - updated : 17-11-2009

HGNC name	Ras association (RalGDS/AF-6) domain family (N-terminal) member 10
HGNC id	33984

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	N-terminal Ras-Association domain
	Ras-association (RA) domains

HOMOLOGY

Homologene

FAMILY

N-terminal RASSF family

CATEGORY

tumor suppressor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
text	subcellular localization is cell-cycle dependent with RASSF10 colocalizing to centrosomes and associated microtubules during mitosis

basic FUNCTION	may function as tumour suppressors by regulating the cell cycle and apoptosis
	potential Ras effector implicated in key biological processes, including cell death, proliferation, microtubule stability, promoter methylation, vesicle trafficking and response to hypoxia
	may encode a novel epigenetically inactivated candidate tumor suppressor gene in thyroid carcinogenesis
	can act as a tumor suppressor gene and is frequently methylated in gliomas

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   by frequent methylation of the associated 5prime-CpG island in acute lymphoblastic leukemia tumoral     --low   CpG island promoter was intensively methylated in nine thyroid cancer cell lines and in primary thyroid carcinomas

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	can potentially be developed into a prognostic marker for secondary glioblastomas
Therapy target

ANIMAL & CELL MODELS