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	HGNC	UniGene	Nucleotide	OMIM	UCSC

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FLASH GENE

Symbol

WWTR1

contributors: mct/npt/pgu - updated : 23-02-2017

HGNC name	WW domain containing transcription regulator 1
HGNC id	24042

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in approximately 20 p100 of breast cancer samples constitutional     --over   in placentas of preeclampsia and HELLP syndrome tumoral fusion       WWTR1-CAMTA1 fusion in all epithelioid hemangioendothelioma tested from bone, soft tissue, and visceral location (liver, lung) in keeping with a unique and specific pathological entity tumoral     --over   in non-small cell lung cancer (NSCLC) tumoral     --over   in high-grade breast cancers constitutional     --low   during decidualization

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer lung   may present a novel target for the future diagnosis, prognosis and therapy of lung cancer

ANIMAL & CELL MODELS