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FLASH GENE
Symbol MACROD1 contributors: mct/npt - updated : 08-07-2009
HGNC name MACRO domain containing 1
HGNC id 29598
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • only a stand-alone macro domain functional module that can
    • serve as the AR coactivator (Yang 2009)
    HOMOLOGY
    Homologene
    FAMILY
  • macro domain superfamily
    • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    basic FUNCTION
  • cooperates with the estrogen receptor alpha and enhances the receptor transcriptional activity in an estrogen-dependent manner (Yang 2009)
  • plays an essential role in AR transactivation (Yang 2009)
  • may be involved in estrogen signaling (Han 2007)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds to androgen receptor (AR) via its macro domain and amplifies the transactivation function of AR in response to androgen (Yang 2009)
  • physically interacts with ERalpha (ESRT1) in a manner that is estrogen independent but is enhanced by estrogen (Han 2007)
    • cell & other
    REGULATION
    Other estrogenically regulated and it can stimulate the proliferation of MCF-7 breast cancer cells (Han 2007)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral fusion      
    with RUNX1 (RUNX1 fusion partner of LRP16 on 11q13 involving t(11;21)(q13;q22) in monocytic leukemia (Imagama (2009)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS