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FLASH GENE

Symbol

WRAP53

contributors: mct/npt/pgu - updated : 02-03-2012

HGNC name	WD repeat containing, antisense to TP53
HGNC id	25522

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

DKCB3

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   correlate with poor prognosis of head and neck cancer constitutional       loss of function loss of WRAP53-mediated SMN trafficking contributes to spinal muscular atrophy (

Susceptibility

to ER negative breast cancers

Variant & Polymorphism other	common variation in TP53 or WRAP53 could be associated with ER negative breast cancers

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer     novel molecular target for a large fraction of malignancies

ANIMAL & CELL MODELS