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FLASH GENE
Symbol WRAP53 contributors: mct/npt/pgu - updated : 02-03-2012
HGNC name WD repeat containing, antisense to TP53
HGNC id 25522
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivemouth   highly
Lymphoid/Immunethymus   highly
Reproductivefemale systemuteruscervix highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • WD repeats
    • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleolus
    text
  • enriched in Cajal bodies, nuclear sites of ribonucleoprotein modification and assembly, and is required for trafficking of telomerase to Cajal bodies
    • basic FUNCTION
  • natural antisense transcript of TP53, that regulates endogenous TP53 mRNA levels and further induction of TP53 protein by targeting the 5' untranslated region of TP53 mRNA
  • controls telomerase trafficking and is required for telomere synthesis in human cancer cells
  • essential for TERC localization to Cajal bodies and for telomere synthesis by telomerase
  • essential factor for Cajal body maintenance and for directing the survival of motor neuron (SMN) complex to Cajal bodies
  • mediates the interaction between SMN and associated proteins, which is important for nuclear targeting of SMN and the subsequent localization of the SMN complex to Cajal bodies
  • telomerase holoenzyme protein that facilitates trafficking of telomerase to Cajal bodies
  • protein essential for Cajal body formation and involved in cellular trafficking of the survival of motor neuron complex, the telomerase enzyme and small Cajal body-specific RNAs to Cajal bodies
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • associates with active telomerase enzyme, established telomerase components, and small Cajal body RNAs that are involved in modifying splicing RNAs
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) DKCB3
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    correlate with poor prognosis of head and neck cancer
    constitutional       loss of function
    loss of WRAP53-mediated SMN trafficking contributes to spinal muscular atrophy (
    Susceptibility to ER negative breast cancers
    Variant & Polymorphism other common variation in TP53 or WRAP53 could be associated with ER negative breast cancers
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancer  
    novel molecular target for a large fraction of malignancies
    ANIMAL & CELL MODELS