Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol SERPIND1 contributors: - updated : 15-05-2006
HGNC name serine (or cysteine) proteinase inhibitor, clade D (heparin cofactor), member 1
HGNC id 4838
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an heparin binding site and a reactive site
  • N-terminal acidic repeat region mediating, in part, the glycosaminoglycan-accelerated thrombin inhibition
    • conjugated GlycoP
    HOMOLOGY
    intraspecies homolog to AT3
    Homologene
    FAMILY serpin family
    CATEGORY enzyme , regulatory
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    basic FUNCTION
  • inhibitor of thrombin and chymotrypsin
  • rapidly inhibiting thrombin in the presence of dermatan sulfate or heparin
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) HCF2
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional   deletion    
    in di Georges syndrome
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS