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FLASH GENE
Symbol CXCL1 contributors: mct - updated : 11-04-2020
HGNC name chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
HGNC id 4602
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional     --over  
in ulcerative colitis, osteoarhtritis
tumoral     --over  
in ovarian cancer
tumoral       gain of function
in ER&8209;negative Breast cancer tissues and cell lines compared with ER&8209;positive tissues and cell lines
tumoral     --over  
obese patients with prostate cancer have increased epithelial CXCL1 expression
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
  • sputum CXCL1 levels is a potentially better diagnostic marker for chronic obstructive pulmonary disease (COPD) than sputum CXCL8 levels, which is explained by that CXCL1 production in bronchial epithelial cells is less affected by therapeutic anti-inflammatory agents
  • CXCL1 may serve as a new biomarker for ColoRectal Cancer
  • urine CXCL1 is a promising, non-invasive molecular marker for tumor detection and outcome prediction in patients with bladder cancer (BCa)
  • urinary CXCL1 is a new non-invasive predictor of IgAN progression
    • Therapy target
    SystemTypeDisorderPubmed
    cancerreproductivebreast
    may serve as a potential therapeutic target in ER‑negative Breast cancer
    cancerreproductiveovary
    therapeutic target as well as a diagnostic marker in ovarian cancer
    cancer  
    targeting CXCL1 for cancer therapy would be applicable to a large portion of human tumors with mutant TP53, but the exploration of CXCL1 as a potential target should take the mutation status of TP53 into consideration
    cancerreproductivebreast
    CXCL1-based therapy might become a novel strategy for breast cancer metastasis prevention
    cancerdigestivecolon
    CXCL1 may serve as a potential therapeutic target for CRC treatment
    cancerdigestivestomach
    CXCL1 produced in T- lymphatic endothelial cells (LECs) represents a potentially promising target for treating gastric cancer
    ANIMAL & CELL MODELS