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FLASH GENE
Symbol GNAZ contributors: npt/mct - updated : 18-01-2006
HGNC name guanine nucleotide binding protein (G protein), alpha z polypeptide
HGNC id 4395
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • GTPase domain made of three regions named switches 1,2 and 3
  • sites for guanine nucleotide binding and effector interaction
  • an helical domain
  • lacking a pertussis modification site
    • conjugated LipoP , Other
    HOMOLOGY
    interspecies ortholog to murine Gnaz
    homolog to C.elegans gpa-16
    Homologene
    FAMILY
  • G-alpha family
  • subfamily 1 (G(I/O/T/Z))
    • CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • mediating signal transduction in pertussis toxin-insensitive systms
  • playing a role in maintaining the ionic balance of perilymphatic and endolymphatic cochlear fluids
  • involved as modulators or transducers in various transmembrane signaling systems
  • inhibits serum response factor-dependent transcription by inhibiting Rho signaling
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • component of PTX insensitive heterotrimeric G-protein complexes
    • INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • GTP
    • protein interacting with RGS20
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS