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FLASH GENE

Symbol

GNAZ

contributors: npt/mct - updated : 18-01-2006

HGNC name	guanine nucleotide binding protein (G protein), alpha z polypeptide
HGNC id	4395

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	54.56 kb     3 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed GNAZ 3 - 3225 41 355 - Dutt (2004)

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver         Nervous brain         Respiratory lung

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	GTPase domain made of three regions named switches 1,2 and 3
	sites for guanine nucleotide binding and effector interaction
	an helical domain
	lacking a pertussis modification site

conjugated

LipoP , Other

HOMOLOGY

interspecies	ortholog to murine Gnaz
	homolog to C.elegans gpa-16

Homologene

FAMILY	G-alpha family
	subfamily 1 (G(I/O/T/Z))

CATEGORY

receptor membrane G

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION	mediating signal transduction in pertussis toxin-insensitive systms
	playing a role in maintaining the ionic balance of perilymphatic and endolymphatic cochlear fluids
	involved as modulators or transducers in various transmembrane signaling systems
	inhibits serum response factor-dependent transcription by inhibiting Rho signaling

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

signal transduction

a component

component of PTX insensitive heterotrimeric G-protein complexes

INTERACTION

DNA

RNA

small molecule	nucleotide,
	GTP

protein

interacting with RGS20

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS