Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol RNF220 contributors: mct - updated : 13-01-2022
HGNC name ring finger protein 220
HGNC id 25552
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one RING-type zinc finger
    • HOMOLOGY
    interspecies homolog to murine Rnf220 (97.9pc)
    Homologene
    FAMILY
  • RING finger protein family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • ubiquitin ligase for SIN3B, promoting its ubiquitination and proteasomal degradation (Kong 2010)
  • can bind E2 and mediate auto-ubiquitination (Kong 2010)
  • potentially novel role of RNF220 in Wnt-related tumorigenesis
  • RNF220 and its cofactor ZC4H2 participate in ventral neural tube patterning by modulating Shh/Gli signaling
  • ubiquitin E3 ligase RNF220 and its co-factor ZC4H2 are required for multiple neural developmental processes through different targets, including spinal cord patterning and the development of the cerebellum and the locus coeruleus
  • having roles and mechanisms of action in signal transduction, vertebrate neural development, and related human disorders
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • ions Zn2+
    • protein
  • interacting specifically with SIN3B (Kong 2010)
  • RNF220 physically interacts with CTNNB1, but instead of promoting its ubiquitination and proteasomal degradation, it stabilizes CTNNB1 and promotes canonical Wnt signaling
  • RNF220 interacts with USP7, a ubiquitin-specific peptidase, which is required for RNF220 to stabilize CTNNB1
  • RNF220 cooperates with ZC4H2 to specify spinal progenitor domains (
  • RNF220 is an E3 ligase promoting the ubiquitination and proteasomal degradation of SIN3B, a chromatin-associated protein, which plays a vital role in chromatin condensation
  • ZC4H2 is required for the stability of RNF220 and also proper Gli ubiquitination and signaling
  • ZC4H2 and RNF220 are likely involved in the regulation of neural stem cell proliferation and differentiation through CEND1
  • RNF220-mediated ubiquitination promotes aggresomal accumulation and autophagic degradation of cytoplasmic GLI via HDAC6
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) HLD23
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional germinal mutation      
    leads to male infertility with small-headed sperm
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Rnf220-null mice show widespread alterations of ventral progenitor domains, including the loss of the p2 domain that produces V2 interneurons