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FLASH GENE

Symbol

SHC4

contributors: mct - updated : 19-03-2009

HGNC name	SHC (Src homology 2 domain containing) family, member 4
HGNC id	16743

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   at the transition from radial growth phase to vertical growth phase and metastatic melanomas, when tumor cells acquire migratory competence and invasive potential

Susceptibility

Variant & Polymorphism

Candidate gene	specific marker of metastatic melanomas (Fagiani 2007)
	might represent a new drugable target for the treatment of metastatic disease
Marker
Therapy target

ANIMAL & CELL MODELS