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FLASH GENE

Symbol

SLC2A2

contributors: mct - updated : 28-05-2014

HGNC name	solute carrier family 2 (facilitated glucose transporter), member 2
HGNC id	11006

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

FBIS

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional germinal mutation     loss of function biallelic SLC2A2 inactivation causes lethal neonatal diabetes

Susceptibility

Variant & Polymorphism SNP	are associated with the conversion from impaired glucose tolerance to type 2 diabetes
	polymorphisms at positions -269, -44, or + 103 may affect GLUT2 gene transcription, possibly associated with reduced expression of the GLUT2 gene in NIDDM patients

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

homozygous mice deficient in GLUT2 are hyperglycemic and relatively hypoinsulinemic and have elevated plasma levels of glucagon, free fatty acids, and beta-hydroxybutyrate