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FLASH GENE
Symbol SLC2A2 contributors: mct - updated : 28-05-2014
HGNC name solute carrier family 2 (facilitated glucose transporter), member 2
HGNC id 11006
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • twelve putative transmembrane segments (12TM)
  • intracellular N and C termini
  • a large extracellular loop with a glycosylation site between TM1 and 2
  • a small and a large intracellular loops,respectively between TM2 and 3 and TM8 and 9,both with the conserved RXGRR motif
    • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to murine Slc2a2
    Homologene
    FAMILY solute carrier family 2 (sugar transporter family), glucose transporter subfamily
    CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    text basolateral membrane
    basic FUNCTION
  • facilitated glucose transporter, involved in glucosamine transport
  • is responsible for uptake of glucose by the beta cells
  • may comprise part of the glucose-sensing mechanism of the beta cell
  • may also participate with the Na(+)/glucose cotransporter in the transcellular transport of glucose in the small intestine and kidney
  • functions as part of the glucose sensing mechanism for the stimulation of insulin secretion (pMID: 19477941)
  • is unlikely to be the principal glucose transporter in human beta-cells
  • important role of SLC2A2 transporter fueling metabolism at body level
  • role important during embryonic period for differentiation of insulin-producing cells and insulin secretion
  • having functions in pancreatic beta cell development
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS facilitated diffusion transport
    PATHWAY
    metabolism carbohydrate
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • hyperglycemia directly affects beta-cell function and activates a trafficking pathway that results in the rapid endocytosis and degradation of the cell surface SLC2A2 glucose transporter
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) FBIS
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional germinal mutation     loss of function
    biallelic SLC2A2 inactivation causes lethal neonatal diabetes
    Susceptibility
    Variant & Polymorphism SNP
  • are associated with the conversion from impaired glucose tolerance to type 2 diabetes
  • polymorphisms at positions -269, -44, or + 103 may affect GLUT2 gene transcription, possibly associated with reduced expression of the GLUT2 gene in NIDDM patients
    • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    homozygous mice deficient in GLUT2 are hyperglycemic and relatively hypoinsulinemic and have elevated plasma levels of glucagon, free fatty acids, and beta-hydroxybutyrate