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FLASH GENE
Symbol HJURP contributors: mct/pgu - updated : 26-06-2012
HGNC name holliday junction recognition protein
HGNC id 25444
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a TLTY box required for the interaction of HJURP with CENPA
  • C-terminal beta-sheet domain of HJURP caps the DNA-binding region of the histone heterodimer, preventing it from spontaneous association with DNA
    • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY chaperone/stress , DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,chromatin/chromosome,centromere
    intracellular,nucleus,nucleolus
    text
  • found at centromeres for two to three hours after anaphase onset7 and may serve, directly or indirectly, as a CENPA chaperone during chromatin assembly
    • basic FUNCTION
  • involved in the homologous recombination pathway in the DSB repair process through interaction with MSH5 and NBS1, which is a part of the MRN protein complex
  • key factor for CENPA deposition and maintenance at centromeres
  • CENPA chaperone, required for cell cycle specific targeting of CENPA to centromeres
  • key chaperone responsible for the targeting and deposition of newly synthesized CENP-A at centromeres
  • CENPA nucleosome assembly activity of HJURP is responsible for centromeric chromatin assembly to maintain the epigenetic mark
  • its stringent regulation is critical for genome stability
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • possible downstream target for ataxia telangiectasia mutated signaling
  • 14-3-3 binding protein
  • CENPA-binding protein , CENPA histone chaperone
  • binds a CENPA-H4 heterodimer
  • WDHD1 interacts with both CENPA and HJURP in a prenucleosomal complex, and the association of WDHD1 with CENPA is increased during the cell cycle transition from mitosis to G1 phase
  • CENPA is a HJURP-interacting partner required for HJURP localization at centromeres
  • HJURP interacts with prenucleosomal CENPA and is required for the centromeric assembly of new CENPA in a process after centromere priming
  • CENPA pre-nucleosomal complex achieves assembly of the octameric CENPA nucleosome through the dimerization of the CENPA chaperone HJURP
    • cell & other
    REGULATION
    Other centromeric localization is cell cycle regulated
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in a majority of lung cancers and associated with poor prognosis as well
    constitutional     --over  
    led to mitotic defects in human cells
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS