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FLASH GENE
Symbol KIF26B contributors: mct/npt - updated : 19-02-2009
HGNC name kinesin family member 26B
HGNC id 25484
Location 1q44      Physical location : 245.318.286 - 245.866.428
Synonym symbol(s) FLJ10157, MGC35030
DNA
TYPE functioning gene
STRUCTURE 548.14 kb     15 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
15 - 7287 223.75 2112 - Venter (2001)
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo
Text
  • limb buds, face, derivatives somites (Marikawa 2004)
  • in the metanephric mesenchyme during nephrogenesis, also detected in the limb buds and central nervous system (Holloway 2010)
    • PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a well conserved motor domain in the N terminus
    • HOMOLOGY
    Homologene
    FAMILY
  • kinesin-like protein family
  • kinesin-11 family
    • CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule
    basic FUNCTION
  • may play a role in embryogenesis, specifically in the development of limbs, face, and somites (Marikawa (2004)
  • essential for kidney development because it regulates the adhesion of mesenchymal cells in contact with ureteric buds (Uchiyama 2010)
  • kinesin family gene, acting downstream of SALL1 and regulates the adhesion of mesenchymal cells surrounding ureteric buds, providing insights into the mechanisms of kidney development (Uchiyama 2010)
  • essential for ureteric bud attraction and could be one of the major functional molecules acting downstream of SALL1 (Uchiyama 2010)
  • may enhance the interaction of MYH10 and actin, thereby stabilizing the cell–cell adhesion of mesenchymal cells in the developing kidney (Uchiyama 2010)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a well conserved motor domain in the N terminus
    • HOMOLOGY
    Homologene
    FAMILY
  • kinesin-like protein family
  • kinesin-11 family
    • CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule
    basic FUNCTION
  • may play a role in embryogenesis, specifically in the development of limbs, face, and somites (Marikawa (2004)
  • essential for kidney development because it regulates the adhesion of mesenchymal cells in contact with ureteric buds (Uchiyama 2010)
  • kinesin family gene, acting downstream of SALL1 and regulates the adhesion of mesenchymal cells surrounding ureteric buds, providing insights into the mechanisms of kidney development (Uchiyama 2010)
  • essential for ureteric bud attraction and could be one of the major functional molecules acting downstream of SALL1 (Uchiyama 2010)
  • may enhance the interaction of MYH10 and actin, thereby stabilizing the cell–cell adhesion of mesenchymal cells in the developing kidney (Uchiyama 2010)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a well conserved motor domain in the N terminus
    • HOMOLOGY
    Homologene
    FAMILY
  • kinesin-like protein family
  • kinesin-11 family
    • CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule
    basic FUNCTION
  • may play a role in embryogenesis, specifically in the development of limbs, face, and somites (Marikawa (2004)
  • essential for kidney development because it regulates the adhesion of mesenchymal cells in contact with ureteric buds (Uchiyama 2010)
  • kinesin family gene, acting downstream of SALL1 and regulates the adhesion of mesenchymal cells surrounding ureteric buds, providing insights into the mechanisms of kidney development (Uchiyama 2010)
  • essential for ureteric bud attraction and could be one of the major functional molecules acting downstream of SALL1 (Uchiyama 2010)
  • may enhance the interaction of MYH10 and actin, thereby stabilizing the cell–cell adhesion of mesenchymal cells in the developing kidney (Uchiyama 2010)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS