Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

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FLASH GENE

Symbol

TRIM72

contributors: mct/npt/shn - updated : 20-03-2017

HGNC name	tripartite motif-containing 72
HGNC id	32671

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene	could be a new candidate for the diagnosis and treatment of patients with Brody syndrome
Marker
Therapy target
	System Type Disorder Pubmed neuromuscular myopathy   great potential for the use of recombinant TRIM72 in treating muscular dystrophy and other diseases in which compromised membrane integrity contributes to the disease cardiovascular cardiomyopathy   . membrane reparative function provides an entirely new model for potential therapy of muscle and cardiovascular diseases, including muscular dystrophy, cardiomyopathy and age-related muscle wasting neuromuscular myopathy   . membrane reparative function provides an entirely new model for potential therapy of muscle and cardiovascular diseases, including muscular dystrophy, cardiomyopathy and age-related muscle wasting diabete metabolic syndrom   novel therapeutic target for treating metabolic disorders and associated cardiovascular complications

ANIMAL & CELL MODELS

	mice null for TRIM72 show progressive myopathy and reduced exercise capability, associated with defective membrane-repair capacity
	remarkable defects in skin architecture and collagen overproduction are observed in mg53(-/-) mice, and these animals display delayed wound healing and abnormal scarrin