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FLASH GENE

Symbol

TRIM72

contributors: mct/npt/shn - updated : 20-03-2017

HGNC name	tripartite motif-containing 72
HGNC id	32671

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       highly Homo sapiens

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal     Homo sapiens Muscular striatum cardiac     Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a RING-type zinc finger
	a B box-type zinc finger
	a B30.2/SPRY domain
	the RBCC motif is followed by the PRY-SPRY domain
	two Zn(2+)-binding motifs with indispensable role to assembly of the cell membrane repair machinery
	a C-terminal PRY-SPRY domain

HOMOLOGY

interspecies	ortholog to Trim72, Mus musculus
	ortholog to Trim72, Rattus norvegicus
	ortholog to TRIM72, Pan troglodytes

intraspecies

homolog to TRIM50

Homologene

FAMILY	TRIM/RBCC family
	C-IV TRIM family
	tripartite motif family protein

CATEGORY

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic,vesicle
text	localized in small vesicles below the plasma membrane

basic FUNCTION	an antagonist of insulin receptor substrate 1, and is essential as a negative regulator of IGF-induced muscle differentiation
	muscle-specific TRIM family protein that is an essential component of the cell membrane repair machinery
	is an essential component of the cell membrane repair machinery
	has an essential role in membrane repair of striated muscle cells
	TRIM50 and TRIM72 may exert similar biological roles in vesicular trafficking below the cell membrane in muscle and parietal cells, respectively
	in addition to its role in vesicular trafficking, TRIM72 likely contributes to proteolysis of specific targets by catalyzing ubiquitination in the RBCC motif
	E2 enzyme UBE2H and the E3 enzyme TRIM72 were up-regulated during myogenesis
	UBE2H and TRIM72 complexes are required for PTK2 ubiquitination and degradation
	essential role for TRIM72 in repair of alveolar epithelial cells under plasma membrane stress failure
	essential component of the cell membrane repair machinery
	trifunctional role for TRIM72 as a facilitator of rapid injury repair, a mediator of cell migration, and a modulator of myofibroblast differentiation during wound healing
	TRIM72 directly and indirectly modulates caveolar endocytosis, an essential process involved in repair of lung epithelial cells through removal of plasma membrane wounds

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

PTK2 formed a complex with its E2 enzyme, UBE2H, and E3 enzyme, TRIM72

INTERACTION

DNA

RNA

small molecule

protein	MYH9 is a key cytoskeleton motor protein that facilitates vesicle trafficking during MG53-mediated cell membrane repair
	binds to sarcoplasmic reticulum Ca(2+)-ATPase 1a (ATP2A1) via its tripartite motif (TRIM) and PRY domains
	acts as an E3 ligase targeting the insulin receptor and IRS1 for ubiquitin-dependent degradation, comprising a central mechanism controlling insulin signal strength in skeletal muscle
	TRIM72 is an ubiquitin E3 ligase that induces IRS1 ubiquitination with the help of an E2-conjugating enzyme, UBE2H
	TRIM72 induces PTK2 ubiquitination with the aid of UBE2H during skeletal myogenesis

cell & other

REGULATION

Other

is transcriptionally activated by the synergism of MYOD1 and MYEF2 (Jung 2010)

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene	could be a new candidate for the diagnosis and treatment of patients with Brody syndrome
Marker
Therapy target
	System Type Disorder Pubmed neuromuscular myopathy   great potential for the use of recombinant TRIM72 in treating muscular dystrophy and other diseases in which compromised membrane integrity contributes to the disease cardiovascular cardiomyopathy   . membrane reparative function provides an entirely new model for potential therapy of muscle and cardiovascular diseases, including muscular dystrophy, cardiomyopathy and age-related muscle wasting neuromuscular myopathy   . membrane reparative function provides an entirely new model for potential therapy of muscle and cardiovascular diseases, including muscular dystrophy, cardiomyopathy and age-related muscle wasting diabete metabolic syndrom   novel therapeutic target for treating metabolic disorders and associated cardiovascular complications

ANIMAL & CELL MODELS

	mice null for TRIM72 show progressive myopathy and reduced exercise capability, associated with defective membrane-repair capacity
	remarkable defects in skin architecture and collagen overproduction are observed in mg53(-/-) mice, and these animals display delayed wound healing and abnormal scarrin