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FLASH GENE
Symbol POMGNT2 contributors: mct - updated : 15-10-2012
HGNC name protein O-linked mannose N-acetylglucosaminyltransferase 2 (beta 1,4-)
HGNC id 25902
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a fibronectin III domain that is not essential for the enzymatic activity of POMGNT2
    • HOMOLOGY
    intraspecies homolog to highly homologous to EOGT
    Homologene
    FAMILY
  • glycosyltransferase 61 family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • glycosyltransferase activity
  • might encode O-GlcNAc transferase that specifically glycosylates DAG1
  • POMGNT2-dependent modification sites are mainly distributed in the O-mannosylated region and not limited to the LARGE-targeting sequence
  • novel glycosyltransferase catalyzing GlcNAcylation in the ER
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • is a novel glycosyltransferase catalyzing GlcNAcylation of O-mannosylated DAG1 in the ER
  • modifies O-mannose on the mucin-like domain of DAG1
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) WLKWS6
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS